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Shaping the Future of Surgery

Over a Century of Meaningful Innovation

At Ethicon, weʼre focused on improving health outcomes for patients and helping solve the greatest health challenges… with only meaningful innovation. The kind that led to the creation of the first sutures, that helped revolutionize surgery with minimally invasive procedures, and that elevates standards of care around the world.

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i. Compared to Mega Soft

ii. Compared to Mega Soft Universal

iii. Ethicon retrospective analysis of economic and clinical outcomes comparing the use of Echelon Powered vs. Medtronic non-powered endoscopic surgical staplers to treat patients undergoing video-assisted thoracoscopic surgery lobectomy. Review of 3,006 cases between 2012 and 2015 from the Premier Perspective® Hospital Database. Data assessed included length of stay, total hospital cost, supply cost, room & board cost, incidence of transfusion, and incidence of hemostasis-related complications; all p ≤ 0.05.

* Benchtop testing in porcine tissue ≤30mmHg (26mmHg average pressure experienced during intra-operative leak test), comparing Ethicon CDH29P to Medtronic (Covidien) manual EEA2835 (p<0.001) and preclinical perfusion model, in which perfusion was not significantly different between devices.

# Based on a pre-clinical study on seal reliability and average time to transect 150mm of porcine jejunum, device measurements based on a metrology study, engineering study of average device tip grasping force and a porcine study comparing sealing times of HARMONIC™ ACE+7™ and HARMONIC™ HD1000i.

† Preclinical test of distal tip bleeding (ENSEAL™ vs. Impact-LF4318) in thick porcine mesentery base (p<0.001).

‡ Challenging tissue - thick, fragile, and varying thickness and density

1. 2017 European Society of Coloproctology (ESCP) Collaborating Group. The 2017 European Society of Coloproctology (ESCP) international snapshot audit of left colon, sigmoid and rectal resections - Executive Summary. Colorectal Dis. 2018;20 [Suppl 6]:13-14.

2. Ethicon, PRC077848 Leak Claims Testing, October 2016, Data on File. Ethicon, PSB004557 A comparison of staple line perfusion between 29mm ECHELON CIRCULAR Powered Stapler (CDH29P) and 28mm DST Series EEA Circular Stapler (EEA2835), November 2016, Data on File (114092-190513 EMEA)

3. Zoucas E, Lydrup ML. Hospital costs associated with surgical morbidity after elective colorectal procedures: a retrospective observational cohort study in 530 patients. Patient Saf Surg. 2014;8(1):2

4. Digestive Cancers Europe. White Paper Colorectal Screening in Europe. Saving Lives & Saving Money. https://digestivecancers.eu/Documents/Uploaded/466-Document-DiCEWhitePaper2019.pdf?l=26058767 Accessed August 28, 2019

5. Ethicon, PRC074111B, Buccaneer DV Grasping Force – Tip Bite, March 2016, Data on file Ethicon, PRC074125B, Buccaneer DV-Vessel Transection Speed, March 2016, Data on file Ethicon, PRC074127B, Buccaneer DV Transection Speed – Marching And Tip Bite, March 2016, Data on file Ethicon, PRC074432A, Buccaneer Energy Vessel Tissue Claims, March 2016, Data on file Ethicon, PRC074607A, Buccaneer Metrology Claims, March 2016, Data on file (118714-190716 EMEA)

6. Ethicon, PSB004548 Final Report Brick Distal Tip Sealing Algo D, Sept 2016, Data on File. Ethicon, PSP005819, Final Report- 2017 Brick Claims: Comparison of distal tip sealing performance between ENSEAL X1 Large Jaw (NSLX120L) and LigaSure Impact (LF4318), Sept 2017, Data on File (116497-190612 EMEA)

7. Ethicon, PRC076031B Tissue Performance Design Verification Test of 45mm Gripping Surface Technology (GST) Reloads with Echelon Flex 45mm Powered Plus Staplers, Sep 2016, Data on file Ethicon, PRC067394A Tissue flow and functional performance of ENDOPATH ECHELON™ Reloads (GST) and Covidien’s reloads with Tri-Staple technology, July 2014, Data on file (113328-190502 EMEA)

8. Ethicon, ENG-RPT-406, Verifcation Testing I, Universal Mega Soft, Oct 2013, Data on File. (115403-190529).

9. Ethicon, 28022018, Universal Plus Equivalency Memo, Feb 2018, Data on File. (115403-190529, 116660-190614, 116652-190614, 116657-190614).

10. Ethicon, 31072019, Megasoft Pad Weights Memo, July 2019, Data on File. (115403-190529).

11. Ethicon, 08032017, Hydrogen Peroxide Cleaning of Mega Soft Return Electrodes (ENG-RPT-519), March 2017, Data on File (116657-190614).

12. Ethicon, 07082019, MegaSoft Sales and Procedures Calculation 2019, Aug 2019, Data on File. (117766-190702).

13. Ethicon Inc, Premier thoracic analysis, Ethicon Powered vs Medtronic manual sample, Data on File.