Transforming Lives Together
Transforming Lives Together

Ethicon is committed to the science and treatment of obesity and in advancing Bariatric Surgery. Learn how Sonya’s bariatric surgery changed her life.

Shaping the Future of Surgery

Over a Century of Meaningful Innovation

At Ethicon, weʼre focused on improving health outcomes for patients and helping solve the greatest health challenges… with only meaningful innovation. The kind that led to the creation of the first sutures, that helped revolutionize surgery with minimally invasive procedures, and that elevates standards of care around the world.

News & Events
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ETHICON LAUNCHES INDUSTRY’S FIRST POWERED CIRCULAR STAPLER FOR COLORECTAL, GASTRIC AND THORACIC SURGERY
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Beyond the Procedure: Using Art to Showcase the Impact of Surgeons on Patient Lives
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Ethicon Announces 510(K) Clearances for VISTASEAL Open and Laparoscopic Dual Applicator Devices Designed to Deliver Biologics That Address Surgical Bleeding
VISTASEAL Dual Applicator is the First Product to Emerge from Recent Strategic Partnership Between Ethicon and Grifols, Leading Maker of Plasma-Derived Medicines
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Pulmonary Artery Branch Sealing with Ultrasonic Energy Device Shows Promise in Minimally Invasive Lung Cancer International Clinical Trial
Preliminary Findings Presented at American Association for Thoracic Surgery Annual Meeting
References

*     Based on number of set-up steps and thawing time required for VISTASEAL™ Dual Applicator vs competition.

‡    System components include ECHELON FLEX™ Powered Plus Stapler and ECHELON ENDOPATH™ Reloads with Gripping Surface Technology.

§    Benchtop testing in porcine tissue ≤30mmHg (26mmHg average pressure experienced during intra-operative leak test), comparing Ethicon ECHELON CIRCULAR™ Powered Stapler     CDH25P to Medtronic DST Series™ EEA™ Stapler EEA2535 (p<0.001) and preclinical perfusion model, in which perfusion was not significantly different between devices.

1.     Bjelovic M, Ayguasonosa J, Kim RD, et al. A prospective, randomized, phase III study to evaluate the eicacy and safety of fibrin sealant Grifols as an adjunct to hemostasis as compared to    
        cellulose sheets in hepatic surgery resections. J Gastrointest Surg. 2018. 22:1939-1949.

2.     VISTASEAL™ Fibrin Sealant (Human). [Highlights of Prescribing Information] Instituto Grifols, S.A. 2018.

3.     Ethicon retrospective analysis of economic and clinical outcomes comparing the use of Echelon Powered vs. Medtronic non-powered endoscopic surgical staplers to treat patients 
         undergoing video-assisted thoracoscopic surgery lobectomy.Review of 3,006 cases between 2012 and 2015 from the Premier Perspective® Hospital Database. Data assessed included 
         length of stay, total hospital cost, supply cost, room & board cost, incidence of transfusion, and incidence of hemostasis-related complications; all p ≤ 0.05.

4.     Sissener T. Suture patterns. Com Anim. 2006;11:14-19. 

5.     Moran ME, Marsh C, Perrotti M. Bidirectional-barbed sutured knotless running anastomosis v classic Van Velthoven suturing in a model system. J Endourol. 2007;21(10):1175-1178. 

6.     Vakil JJ, O'Reilly MP, Sutter EG, Mears SC, Belko SM, Khanuja HS. Knee arthrotomy repair with a continuous barbed suture: a biomechanical study. J Arthroplasty. 2011;26(5):710-713. 

7.     Nonnenman H. 100326296: Time zero tissue holding - Competitive claims comparisons for STRATAFIX Knotless Tissue Control Devices vs various products. 2015. Ethicon, Inc. 

8.     Levine BR, Ting N, Della Valle CJ. Use of a barbed suture in the closure of hip and knee arthroplasty wounds. Orthopedics. 2011;34(9):e473-e475. doi: 10.3928/01477447-20110714-35. 

9.     Einarsson JI, Chavan NR, Suzuki Y, Jonsdottir G, Vellinga TT, Greenberg JA. Use of bidirectional barbed suture in laparoscopic myomectomy: evaluation of perioperative outcomes,     safety, and efficacy. J Minim Invasive Gynecol. 2011;18(1):92-95. 

10.     Eickmann T, Quane E. Total knee arthroplasty closure with barbed sutures. J Knee Surg. 2010;23(3):163-167. 

11.     Ming X, Rothenburger S, Yang D. In vitro antibacterial efficacy of Monocryl Plus Antibacterial Suture (poliglecaprone 25 with triclosan). Surg Infect (Larchmt). 2007;8(2):201-207. 

12.     Ming X, Rothenburger S, Nichols MM. In vivo and in vitro antibacterial efficacy of PDS Plus (polidioxanone with triclosan) suture. Surg Infect (Larchmt). 2008;9(4):451-457.

13.     US Market Share Report, October 2016. Ethicon, Inc.

14.     SURGICEL® Technical Report, 2018. Ethicon, Inc.

15.     Hong YM, Loughlin KR. The use of hemostatic agents and sealants in urology. J Urol. 2006;176(6 Pt 1):2367-2374.

16.     SURGICEL® Absorbable Hemostat. Full Prescribing Information. Ethicon, Inc.

17.     Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. doi:10.1001/    jamasurg.2017.0904.

18.     WHO Global Guidelines for the Prevention of Surgical Site Infection, 2016.

19.     Ban KA, Minei JP, Laronga C, et al. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. J Am Coll Surg. 2016;224:59-74.

20.    Moran ME, Marsh C, Perrotti M. Bidirectional-barbed sutured knotless running anastomosis v classic Van Velthoven suturing in a model system. J Endourol. 2007;21(10):1175-1178.
 

21.    Vakil JJ, O’Reilly MP, Sutter EG, Mears SC, Belkoff SM, Khanuja HS. Knee arthrotomy repair with a continuous barbed suture: a biomechanical study. J Arthroplasty. 2011;26(5):710-713. 


22.    Eickmann T, Quane E. Total knee arthroplasty closure with barbed sutures. J Knee Surg. 2010;23(3):163-167. 


23.    Levine BR, Ting N, Della Valle CJ. Use of a barbed suture in the closure of hip and knee arthroplasty wounds. Orthopedics. 2011;34(9):e473-e475. doi: 10.3928/01477447-20110714-35.


24.    Einarsson JI, Chavan NR, Suzuki Y, Jonsdottir G, Vellinga TT, Greenberg JA. Use of bidirectional barbed suture in laparoscopic myomectomy: evaluation of perioperative outcomes, safety, and efficacy. J Minim Invasive Gynecol. 2011;18 (1):92-95. 

25.    P960052B.

26.    Data on File. Keplinger 07PD0748. Protocol investigation of the comparison of PRINEO with conventional wound closure techniques.

27.    Rothenburger S, Spangler D, Bhende S, Burkley D. In vitro antimicrobial evaluation of coated Vicryl Plus Antibacterial Suture (coated polyglactin 910 with triclosan) using zone of inhibition assays. Surg Infect. 2002;3(suppl):S79-S87  

VISTASEAL™ Fibrin Sealant (Human) IMPORTANT SAFETY INFORMATION

INDICATION
VISTASEAL™ is indicated as an adjunct to hemostasis for mild to moderate bleeding in adults undergoing surgery when control of bleeding by standard surgical techniques (such as suture, ligature, and cautery) is ineffective or impractical.  VISTASEAL is effective in heparinized patients.

CONTRAINDICATIONS
Do not inject directly into the circulatory system. 
Do not use for the treatment of severe or brisk arterial bleeding.
Do not use in patients with history of anaphylaxis or severe systemic reactions to human blood products.
Do not use VISTASEAL for spraying unless the minimum recommended distance from the applicator tip to the bleeding site can be achieved. 

WARNINGS AND PRECAUTIONS 
Thromboembolic events may occur if VISTASEAL is administered intravascularly. 
Only spray VISTASEAL if it is possible to accurately judge the distance from the spray tip to the tissue surface. 
Hypersensitivity reactions can occur. 
May carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. 

ADVERSE REACTIONS
The most common adverse reactions (reported in >1% of clinical trial subjects) were nausea and procedural pain. 
For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.

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