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New Knee System Designed to Address Unmet Needs and Deliver High Level of Stability and Optimum Range of Motion

WARSAW, IN – (March 20, 2013) – Today DePuy Synthes Joint Reconstruction Division of DePuy Orthopaedics, Inc., a global leader in devices for joint replacement, widely introduces its latest innovation in total knee replacement—the ATTUNE™ Knee System—at the 2013 American Academy of Orthopaedic Surgeons (AAOS) annual meeting in Chicago. Created as a result of more than six years of extensive research to address unmet patient, surgeon and provider needs, the ATTUNE Knee is an advancement in knee replacement options. It is designed to provide better range of motion and address the unstable feeling some patients experience during everyday activities, such as stair descent and bending.

“Given that studies show 10 to 20 percent of knee replacement patients aren’t completely satisfied with their knee replacement,i  we dedicated a significant amount of resources to designing a knee that would help to address these concerns. The ATTUNE Knee is the result of our largest research and development project ever,” said Hannah McEwen, Worldwide Director for Knee Product Development, DePuy Synthes Joint Reconstruction. “To date, more than 3,500 patients have received an ATTUNE Knee as part of a limited launch and we’ve received positive feedback regarding patient recovery, stability and motion.”

Through a research collaboration with the University of Denver, DePuy Synthes Joint Reconstruction evaluated contemporary knee designs to assess how implant geometry aids in maintaining stability through patient’s daily activities. The research is being presented as a scientific exhibit at AAOS. Additional research with a team of surgeon and industry experts from around the world led to several patented technologies for the ATTUNE Knee. This research included x-rays of patient movement, cadaver knees and computer simulations. The resulting proprietary technologies include:

  • ATTUNE GRADIUS™ Curve: A gradually reducing radius that provides optimum conformity throughout the range of motion and is designed to achieve anterior/posterior stability.
  • SOFCAM™ Contact: An S-curve design that provides a smooth engagement for stability through flexion, while reducing stresses placed on the implant.
  • LOGICLOCK™ Tibial Base: A locking design that provides the architecture to optimize kinematics while reducing wear to the lowest reported levels in the industry.ii  As a result, surgeons do not have to compromise on component size, picking the optimum size and fit for each patient from the range of sizing options.
  • GLIDERIGHT™ Articulation: A design to accommodate patient variation and soft tissue interaction, while optimizing patella tracking.

“With the advanced technologies of the ATTUNE Knee, surgeons like myself are able to offer patients a new knee replacement option that provides freedom to move while remaining stable during everyday activities,” said Dr. William Barrett*, ATTUNE Knee System Design Team Surgeon. “I was excited to be part of the extensive research process that led to the ATTUNE Knee. My experience with the ATTUNE Knee has been very positive, including feedback from my patients who have received the ATTUNE Knee and have returned to doing the things they enjoy.”  

As part of the ATTUNE Knee research and development, DePuy Synthes Joint Reconstruction also developed INTUITIONTM Instruments, which are compatible with the ATTUNE Knee and are designed to help the surgeon deliver stability in motion. The INTUITION Instruments enable surgeons to provide more efficient patient care through the following features:

  • Novel use of composite materials in orthopaedic instruments.
  • Single-layer instrument cases that are lightweight with fewer instruments, reducing weight by 51 percent as compared to previously available instruments. The instruments also minimize the number of cases in the operating room (OR) while maintaining durability.
  • Designed clarity through the use of color coding and clear markings, potentially reducing OR surgical errors.
  • Reduction of surgical steps to help provide set-up efficiency.

In addition to the U.S. introduction, DePuy Synthes Joint Reconstruction plans to make the ATTUNE Knee commercially available in select countries outside the U.S. later this year.  

Important Safety Information
The performance of hip or knee replacements depends on a patient’s age, weight, activity level and other factors. There are potential risks and recovery takes time. People with conditions limiting rehabilitation should not have these surgeries. Only an orthopaedic surgeon can determine if hip or knee replacement is necessary based on an individual patient's condition.

About DePuy Synthes Joint Reconstruction
DePuy Synthes Joint Reconstruction, a global leader in hip, knee and shoulder replacement, is part of DePuy Synthes Companies of Johnson & Johnson, the largest provider of orthopaedic and neurological solutions in the world. For more information visit, .

*Consultant to DePuy Synthes Joint Reconstruction  

(This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. The reader is cautioned not to rely on these forward-looking statements. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could vary materially from the expectations and projections of DePuy Orthopaedics, Inc. and/or Johnson & Johnson. Risks and uncertainties include, but are not limited to, general industry conditions and competition; economic factors, such as interest rate and currency exchange rate fluctuations; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approvals; challenges to patents; changes in behavior and spending patterns or financial distress of purchasers of health care products and services; changes to governmental laws and regulations and domestic and foreign health care reforms; trends toward health care cost containment; and increased scrutiny of the health care industry by government agencies. A further list and description of these risks, uncertainties and other factors can be found in Exhibit 99 of Johnson & Johnson’s Annual Report on Form 10-K for the fiscal year ended December 30, 2012. Copies of this Form 10-K, as well as subsequent filings, are available online at , or on request from Johnson & Johnson. Neither DePuy Orthopaedics, Inc. nor Johnson & Johnson undertake to update any forward-looking statements as a result of new information or future events or developments.)

iBaker PN, van der Meulen JH, Lewsey J, Gregg PJ. The Role of Pain and Function in Determining Patient Satisfaction After Total Knee Replacement. JBJS-Br. 2007; 89-B(7): 893-900.  ii Leisinger S, Hazebrouck S, Deffenbaugh D, Heldreth M. Advanced Fixed Bearing TKA Locking Mechanism Minimizes Backside Micromotion. International Society for Technology in Arthroplasty (ISTA) Annual Meeting. 2011.