MONOVISC® High Molecular Weight Hyaluronan

MONOVISC® High Molecular Weight Hyaluronan is an FDA approved treatment made from ultra-pure hyaluronan, a naturally occurring lubricant found in healthy knee joints. MONOVISC® is a non-avian sourced viscosupplement that provides early and durable pain relief in a single high concentration injection that is conveniently packaged in a 4 mL volume for ease of use by physicians and minimum injection discomfort for patients.

As OA of the knee progresses, prescription medications such as NSAIDs, COX-2 Inhibitors and intraarticular corticosteroid injections may be appropriate next course of therapy choices. Due to contraindications, co-morbidities or adverse events, COX-2 Inhibitors and/or NSAIDs may or may not be an appropriate choice.
These treatments may have provided relief to date but may no longer seem effective due to the disease state progression. A next-step consideration in the Continuum of Care for Knee Osteoarthritis is Hyaluronic Acid (HA) Injections, such as MONOVISC®.

MONOVISC® High Molecular Weight Hyaluronan

Features & Benefits

  • High HA (Hyaluronic Acid) Concentration

    High HA (Hyaluronic Acid) Concentration

    High concentration maximizes the potential for impacting osteoarthritic cell function and restoring native HA production. MONOVISC is delivered as a 4 mL injection with an HA concentration 88mg per injection.1




Supporting Documentation


MONOVISC® White Paper

My Visco™ Patient Brochure

MONOVISC® Patient Brochure


1. Mitek Sports Medicine. “Clinical Efficacy and Safety of MONOVISC® High Molecular Weight Hyaluronan” June 2014. DSUS/MTK/0714/-232

Indication Statement

Indications for Use

Monovisc™ is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen).

MONOVISC® Hyaluronan may enhance the viscoelastic properties of synovial fluid to relieve pain and increase mobility

MONOVISC® is manufactured by and is a registered trademark of Anika Therapeutics, Inc.

All medical devices have associated risks. Please refer to the package insert and other labeling for a complete list of indications, contraindications, precautions and warnings. For further information on DePuy Synthes Products, please contact your local DePuy Synthes Representative.