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PDS® Plus Antibacterial (polydioxanone) Suture
With 4 to 6 weeks of tissue support, PDS Plus Sutures are particularly useful when you need a combination of an absorbable suture and extended wound support.1 Inhibition of bacterial colonization on the suture was shown in vitro and in vivo.2
Features & Benefits
Shown to reduce SSI risk, supported by Level 1A evidence3,4
Meta-analysis—considered Level 1A evidence4—demonstrated a 28% reduction in surgical site infection (SSI) risk with the use of triclosan-coated sutures.3*† In the same study, meta-regression analysis demonstrated that the effect of triclosan-coated sutures in reducing the risk of SSI did not vary by Centers for Disease Control and Prevention (CDC) wound classification or suture type.3*†‡
A cost-effective part of an SSI-prevention bundle
A single SSI can cost up to $39,000.6|| But, at up to $5 more per surgery than traditional sutures,5§ Plus Sutures are an affordable part of the SSI-prevention care bundle recommended by the World Health Organization (WHO).7¶
Recommended by 6 independent authorities¶
Triclosan-coated sutures are included in SSI-prevention bundles recommended by the CDC, ACS/SIS, WHO, NICE, and RKI.6-10
Benefit from Plus Antibacterial Technology in barbed sutures, too
STRATAFIX™ Knotless Tissue Control Devices, made from the same polymers as traditional Ethicon sutures, are the only commercially available barbed sutures with triclosan, which inhibits methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), and other bacteria linked to SSIs.12#**††
*21 RCTs, 6462 patients, 95% CI: (14, 40%), P<0.001.
†All triclosan-coated sutures in these RCTs were Ethicon Plus Antibacterial Sutures (MONOCRYL® Plus Antibacterial [poliglecaprone 25] Suture, Coated VICRYL® Plus Antibacterial [polyglactin 910] Suture, and PDS® Plus Antibacterial [polydioxanone] Suture).
‡Clean wounds 10 RCTs, 2842 patients, 95% CI: (11-43%), P=0.003; non-clean wounds 14 RCTs, 3620 patients, 95% CI: (7-42%).
||As shown in coronary artery bypass surgery.
§On average, compared to traditional sutures.
¶Guidelines on reducing the risk of surgical site infections are general to triclosan-coated sutures and are not specific to any one brand.
#In preclinical studies ex vivo model.
**PDS Plus and MONOCRYL Plus sutures only.
††Staphylococcus aureus, Staphylococcus epidermidis, methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE), Escherichia coli, and Klebsiella pneumoniae.
‡‡Refers only to STRATAFIX™ Symmetric PDS™ Plus, STRATAFIX™ Spiral PDS™ Plus, and STRATAFIX™ Spiral Monocryl™ Plus.
1. PDS® Plus Antibacterial (polydioxanone) Suture Instructions for Use. Ethicon, Inc.
2. Ming X, Rothenburger S, Nichols MM. In vivo and in vitro antibacterial efficacy of PDS Plus (polidioxanone with triclosan) suture. Surg Infect (Larchmt). 2008;9(4):451-457.
3. de Jonge SW, Atema JJ, Solomkin JS, Boermeester MA. Meta-analysis and trial sequential analysis of triclosan-coated sutures for the prevention of surgical-site infection. Br J Surg. 2017;104(2):e118-e133.
4. Oxford Centre for Evidence-based Medicine. Levels of Evidence. March, 2009. https://www.cebm.net/2009/06/oxford-centre-evidence-based-medicine-levels-evidence-march-2009/. Accessed September 8, 2020.
5. Plus Suture Cost Analysis. 2019 Ethicon, Inc.
6. de Lissovoy G, Pan F, Patkar A, et al. Surgical Site Infection Incidence and Burden Assessment Using Multi-institutional Real-world Data. Presented at: EU ISPOR Meeting; November 5-8, 2011; Madrid, Spain.
7. World Health Organization Global Guidelines for the Prevention of Surgical Site Infection, 2018. https://apps.who.int/iris/bitstream/handle/10665/277399/9789241550475-eng.pdf. Accessed May 9, 2020.
8. Berríos-Torres SI, Umscheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017. JAMA Surg. 2017;152(8):784-791. doi:10.1001/jamasurg.2017.0904.
9. Ban KA, Minei JP, Laronga C, et al. American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update. J Am Coll Surg. 2016;224(1):59-74.
10. National Institute for Health and Care Excellence (NICE) Guideline. Surgical site infections: prevention and treatment. NICE website. https://www.nice.org.uk/guidance/ng125/chapter/Recommendations#closure-methods. Accessed July 2, 2020.
11. Prevention of postoperative wound infections. Recommendation of the Committee for Hospital Hygiene and Infection Prevention (KRINKO) at the Robert Koch Institute. Bundesgesundheitsbl. 2018;61(4):448-473.
12. Bhende S, Burkley D, Nawrocki J. In vivo and in vitro anti-bacterial efficacy of absorbable barbed polydioxanone monofilament tissue control device with triclosan. Surg Infect (Larchmt). 2018;19(4):430-437.
© Ethicon US, LLC. 2019. 085133-171129
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